ABSTRACT

ABSTRACT • It is proposed that anoctamin 1 represents a candidate as anionic channel sensitive to cell volume in insulin-producing cells. This proposal is based on experimental results concerning the expression of messenger RNA for this protein and its presence documented by immunohistochemistry in pancreatic islets and the effect of tannic acid and another inhibitor of anoctamin 1 upon the volume of islet cells, insulin secretion, glucose metabolism in pancreatic islets, the bioelectrical activity of beta cells and the transport of chloride anions activated by calcium via channels present in patches of plasma membrane excised from the same cells.